Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human ULBP2
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety or secreted Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6
ABclonal Technology PE Rabbit anti-Human CD146 mAb
Melanoma cell adhesion molecule (MCAM MUC18 CD146) is an immunoglobulin superfamily member that acts as a cell surface adhesion protein and a marker of melanoma progression and metastasis It is expressed in vascular endothelial cells activated T lymphocytes smooth muscle and bone marrow stromal cells MCAM expression increases in endothelial cells in angiogenesis-related disorders including inflammatory bowel disease Crohn s disease rheumatoid arthritis tumors and chronic renal failure In the hematopoietic microenvironment MCAM-expressing human mesenchymal stromal cells (hMSC) maintain hematopoietic stem and progenitor cell (HSPC) self-renewal MCAM also plays a role in multiple sclerosis facilitating lymphocyte transmigration across the blood-brain barrier leading to inflammatory lesions in the central nervous system
ABclonal Technology 647 Rabbit anti-Human GP6/GPVI
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11) Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene
ABclonal Technology 450 Rabbit anti-Human CD45RA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 488 Rabbit anti-Human CD52
Involved in positive regulation of cytosolic calcium ion concentration Predicted to be located in extracellular region and plasma membrane Predicted to be intrinsic component of plasma membrane Predicted to be active in sperm midpiece
ABclonal Technology 647 Rabbit anti-Human/ FOXP3
The protein encoded by this gene is a member of the forkhead winged-helix family of transcriptional regulators Defects in this gene are the cause of immunodeficiency polyendocrinopathy enteropathy X-linked syndrome (IPEX) also known as X-linked autoimmunity-immunodeficiency syndrome Alternatively spliced transcript variants encoding different isoforms have been identified
ABclonal Technology PE Rabbit anti-Human CD61 mAb
The ITGB3 protein product is the integrin beta chain beta 3 Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain A given chain may combine with multiple partners resulting in different integrins Integrin beta 3 is found along with the alpha IIb chain in platelets Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling
Jackson Immuno Research Labs Fluorescein (FITC)-AffiniPure Rabbit Anti-Human IgG + IgM (H+L) (min X Ms Sr Prot)
Fluorescein (FITC)-AffiniPure Rabbit Anti-Human IgG + IgM (H+L) (min X Ms Sr Prot)
ABclonal Technology 647 Rabbit anti-Human FceR1a
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules mediators such as histamine that are responsible for allergy symptoms are released This receptor is comprised of an alpha subunit a beta subunit and two gamma subunits The protein encoded by this gene represents the alpha subunit
ABclonal Technology 594 Rabbit anti-Human FceR1a
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules mediators such as histamine that are responsible for allergy symptoms are released This receptor is comprised of an alpha subunit a beta subunit and two gamma subunits The protein encoded by this gene represents the alpha subunit
ABclonal Technology APC Rabbit anti-Human EGFR mAb
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation Mutations in this gene are associated with lung cancer
ABclonal Technology 647 Rabbit anti-Human CD98
This gene is a member of the solute carrier family and encodes a cell surface transmembrane protein The protein exists as the heavy chain of a heterodimer covalently bound through di-sulfide bonds to one of several possible light chains The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids Alternatively spliced transcript variants encoding different isoforms have been characterized
ABclonal Technology PE Rabbit anti-Human CD22 mAb
Predicted to enable CD4 receptor binding activity protein phosphatase binding activity and sialic acid binding activity Involved in B cell activation negative regulation of B cell receptor signaling pathway and regulation of endocytosis Located in early endosome and recycling endosome
ABclonal Technology PE Rabbit anti-Human NG2 mAb
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells
ABclonal Technology 647 Rabbit anti-Human GATA3
This gene encodes a protein which belongs to the GATA family of transcription factors The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia